Myogenin Recombinant Rabbit Monoclonal Antibody [JE60-39]

Function

Myogenin, is a transcriptional activator encoded by the MYOG gene. Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is a member of the MyoD family of transcription factors, which also includes MyoD, Myf5, and MRF4. In mice, myogenin is essential for the development of functional skeletal muscle. Myogenin is required for the proper differentiation of most myogenic precursor cells during the process of myogenesis. When the DNA coding for myogenin was knocked out of the mouse genome, severe skeletal muscle defects were observed. Mice lacking both copies of myogenin (homozygous-null) suffer from perinatal lethality due to the lack of mature secondary skeletal muscle fibers throughout the body. In cell culture, myogenin can induce myogenesis in a variety of non-muscle cell types.

Background References

1. Becker R et al. Myogenin controls via AKAP6 non-centrosomal microtubule-organizing center formation at the nuclear envelope. Elife. 2021 Oct

2. Khilji S et al. Dissecting myogenin-mediated retinoid X receptor signaling in myogenic differentiation. Commun Biol. 2020 Jun

Subcellular Location

Nucleus.

UNIPROT

SwissProt: P15173 Human

SwissProt: P12979 Mouse

SwissProt: P20428 Rat

Synonyms