IFT88 Recombinant Rabbit Monoclonal Antibody [JE64-77]

Function

Intraflagellar transport protein 88 homolog is a protein that is encoded by the IFT88 gene. This gene encodes a member of the tetratrico peptide repeat (TPR) family. Mutations of a similar gene in mouse can cause polycystic kidney disease. Two transcript variants encoding distinct isoforms have been identified for this gene. In 2012 a mutation was found to be responsible for a novel form of ciliopathy and anosmia in humans capable of remedy in mice by adenoviral mediated gene therapy. IFT88 has been shown to interact with BAT2 and WDR62.[8][9] WDR62 is required for IFT88 localization to the cilia basal body and the cilia axoneme.

Background References

1. Kitamura A et al. Ift88 is involved in mandibular development. J Anat. 2020 Feb

2. Wang S et al. IFT88 deficiency in proximal tubular cells exaggerates cisplatin-induced injury by suppressing autophagy. Am J Physiol Renal Physiol. 2021 Sep

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, Cell projection, cilium, cilium basal body, flagellum.

UNIPROT

SwissProt: Q13099 Human

SwissProt: Q61371 Mouse

Entrez Gene: 305918 Rat

Synonyms