OXGR1 Recombinant Rabbit Monoclonal Antibody [JE64-04] (HA721074)

UNIPROT #

Q96P68

PROTEIN NAME

OXGR1

SYNONYMS

2 oxoglutarate receptor 1 antibody;2-oxoglutarate receptor 1 antibody;aKGR antibody;Alpha ketoglutarate receptor 1 antibody;Alpha-ketoglutarate receptor 1 antibody;G Protein Coupled Receptor 80 antibody;G Protein Coupled Receptor 99 antibody;G-protein coupled receptor 80 antibody;G-protein coupled receptor 99 antibody;GPR80 antibody;GPR99 antibody;MGC119206 antibody;MGC119207 antibody;MGC119208 antibody;OXGR 1 antibody;Oxgr1 antibody;OXGR1_HUMAN antibody;Oxoglutarate (alpha ketoglutarate) receptor 1 antibody;Oxoglutarate receptor 1 antibody;P2RY15 antibody;P2Y like GPCR antibody;P2Y like nucleotide receptor antibody;P2Y purinoceptor 15 antibody;P2Y-like GPCR antibody;P2Y-like nucleotide receptor antibody;P2Y15 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

2-Oxoglutarate receptor 1 (OXGR1), also known as cysteinyl leukotriene receptor E (CysLTE) and GPR99, is a protein that in humans is encoded by the OXGR1 (also termed GPR99) gene. The Gene has recently been nominated as a receptor not only for 2-oxogluterate (see alpha-Ketoglutaric acid) but also for the three cysteinyl leukotrienes (CysLTs), particularly leukotriene E4 (LTE4) and to far lesser extents LTC4 and LTE4. Recent studies implicate GPR99 as a cellular receptor which is activated by LTE4 thereby causing these cells to contribute to mediating various allergic and hypersensitivity responses. Montelucast is in use to treat various conditions including asthma, exercise-induced bronchoconstriction, allergic rhinitis, primary dysmenorrhoea (i.e. dysmenorrhoea not associated with known causes; see dysmenorrhea#Causes), and urticaria. It has been presumed that this drug's beneficial effects in these diseases is due to its well-known ability to act as a receptor antagonist for the cysteinyl leukotriene receptor 1, i.e. it binds to but does not activate this receptor thereby interfering with LTD4, LTC4, and LTE4 provocative actions by blocking their binding to CysLTR1.