AAMP Recombinant Rabbit Monoclonal Antibody [JE64-70]

Function

Angio-associated, migratory cell protein, also known as AAMP, is a protein which in humans is encoded by the AAMP gene. This protein has been conserved in evolution and is so common to many mammals. It is found to be expressed strongly in the cytosol of endothelial cells, cytotrophoblasts, and poorly differentiated colon adenocarcinoma cells found in lymphatics and has been observed at the luminal edges of endometrial cells and in the extracellular environment of vascular-associated mesenchymal cells. AAMP helps to regulate vascular endothelial cell migration regulation and angiogenesis, with other signaling pathway like RhoA/Rho-kinase signaling. In all these diseases we can observe the expression of the AAMP gene. This one can either remain stable, increase or decrease depending on the disease. List of the diseases : gastrointestinal stromal tumor (GIST) (for this disease and the ductal carcinomas, the expression levels are to correlate with necrosis in situ), myeloid leukemia (chronic (CML) and acute (AML) forms), lymphoma, breast cancer, glial brain tumors, colon neoplasia, epidermoid carcinoma, cervical cancer, ovarian cancer, papillary thyroid cancer, pulmonary cancer, atherosclerosis, restenosis.

Background References

1. Yao S. et. al. Angio-associated migratory cell protein (AAMP) interacts with cell division cycle 42 (CDC42) and enhances migration and invasion in human non-small cell lung cancer cells. Cancer Lett. 2021 Apr

2. Wu Y. et. al. AAMP promotes colorectal cancermetastasis by suppressing SMURF2-mediatedubiquitination and degradation of RhoA. Mol Ther Oncolytics. 2021 Nov

Subcellular Location

Cell membrane, Cytoplasm.

UNIPROT

SwissProt: Q13685 Human

Entrez Gene: 227290 Mouse

Entrez Gene: 301512 Rat

Synonyms

AAMP antibody

Angio associated migratory cell protein antibody