FITC Conjugated Human CD200 Recombinant Rabbit Monoclonal Antibody [PSH01-48]
Antibody Type
Recombinant Rabbit monoclonal Antibody
Immunogen
Recombinant protein within human CD200 aa 1-259 / 278.
Species Reactivity
Human
Validated Applications
FC
Target Molecular Weight
Predicted band size: 31 kDa
Positive Control
Mouse peripheral blood.
Conjugation
FITC
Clone Number
PSH01-48
Reactivity Data
Tested Verified (internally validated)
Published Reported in literature (not internally validated)
Predicted Predicted reactive (based on sequence homology)
Not recommended Not recommended (failed internal validation)
FC
Human
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Lot Concentration Lookup
Storage Instructions
Store at 2-8℃. Avoid freeze.
Storage Buffer
Supplied in phosphate-buffered solution, pH 7.2, containing 0.2% ProClean 950 and BSA.
Isotype
IgG
Purification Method
Protein A affinity purified.
Application Dilution
FC
5 µl per million cells in 100 µl staining volume or 5 µl per 100 µl of whole blood.
Target
Function
OX-2 membrane glycoprotein, also named CD200 (Cluster of Differentiation 200) is a human protein encoded by the CD200 gene. CD200 gene is in human located on chromosome 3 in proximity to genes encoding other B7 proteins CD80/CD86. In mice CD200 gene is on chromosome 16. The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two IgSF immunoglobulin domains, transmembrane region and a 19 amino acid long cytoplasmatic domain. CD 200 belongs to the immunoglobulin superfamily, particularly belongs to the B7 receptor family.
Background References
1. Kotwica-Mojzych K et al. CD200:CD200R Interactions and Their Importance in Immunoregulation. Int J Mol Sci. 2021 Feb
2. Choueiry F et al. CD200 promotes immunosuppression in the pancreatic tumor microenvironment. J Immunother Cancer. 2020 Jun