iFluor™ 488 Conjugated Cytokeratin 9 Recombinant Rabbit Monoclonal Antibody [SD201-09]

Function

Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratin 9 is an unusually large, type I acidic cytokeratin that differentiates human plantar and palmar epidermal cells. Cytokeratin 9 localizes to the suprabasal layers as well as the upper epidermal layers such as the glandular ridges and interridges. The domains of cytokeratin 9 include a head, an α-helical coiled-coil-forming rod, and a tail; cytokeratin 9 shares significant homology with cytokeratin 10. Mutations in the cytokeratin 9 gene correlate with the development of epidermolytic palmoplantar keratoderma (EPPK), an autosomal dominant inherited skin disorder that is characterized by hyperkeratosis of the skin over the palms and soles.

Background References

1. De Rosa, L. et al. 2014. Long-term stability and safety of transgenic cultured epidermal stem cells in gene therapy of junctional epidermolysis bullosa. Stem Cell Reports. 2: 1-8.

2. Rice RH et al. 2013. Distinguishing ichthyoses by protein profiling. PLoS One 8:e75355.

Subcellular Location

Extracellular exosome, membrane, nucleus.

UNIPROT

SwissProt: P35527 Human

SwissProt: Q6RHW0 Mouse

Synonyms