iFluor™ 488 Conjugated Cytokeratin 6 Recombinant Rabbit Monoclonal Antibody [SN71-07]

Function

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins, which are useful markers of tissue differentiation, also aid in the characterization of malignant tumors. IL-1 and TNFα induce transcription of cytokeratin 6 in epidermal keratinocytes via the C/EBP β transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies.

Background References

1. Kubo A., et al. 2013. Collapse of the keratin filament network through the expression of mutant keratin 6c observed in a case of focal plantar keratoderma. J. Dermatol. 40:553-557.

2. Akasaka E., et al. 2011. Diffuse and focal palmoplantar keratoderma can be caused by a keratin 6c mutation. Br. J. Dermatol. 165:1290-1292.

Subcellular Location

Keratin filament, cytosol, extracellular exosome, nucleus, membrane.

UNIPROT

SwissProt: P02538 Human

SwissProt: P04259 Human

SwissProt: P48668 Human

Synonyms