MATH1 / HATH1 Recombinant Rabbit Monoclonal Antibody [JE60-25]

Function

Protein atonal homolog 1 is a protein that in humans is encoded by the ATOH1 gene. This protein belongs to the basic helix-loop-helix (BHLH) family of transcription factors. It activates E-box dependent transcription along with TCF3 (E47). ATOH1 is required for the formation of both neural and non-neural cell types. Using genetic deletion in mice, Atoh1 has been shown to be essential for formation of cerebellar granule neurons, inner ear hair cells, spinal cord interneurons, Merkel cells of the skin, and intestinal secretory cells (goblet, enteroendocrine, and Paneth cells). ATOH1 is a mammalian homolog of the Drosophila melanogaster gene atonal. ATOH1 is considered part of the Notch signaling pathway. In 2009, ATOH1 was identified as a tumor suppressor gene.

Background References

1. Castellino RC. et. al. Atoh1/MATH1 Adds Up to Ciliogenesis for Transducing SHH Signaling in the Cerebellum. Dev Cell. 2019 Jan

2. Zhong C. et. al. Atoh1 and other related key regulators in the development of auditory sensory epithelium in the mammalian inner ear: function and interplay. Dev Biol. 2019 Feb

Subcellular Location

Nucleus.

UNIPROT

SwissProt: Q92858 Human

SwissProt: P48985 Mouse

SwissProt: D3ZQL9 Rat

Synonyms