RPS6 Recombinant Mouse Monoclonal Antibody [A6B8-R]

Function

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Background References

1. Yan M. et. al. mTORC1/rpS6 signaling complex modifies BTB transport function: an in vivo study using the adjudin model. Am J Physiol Endocrinol Metab. 2019 Jul

2. Wu S. et. al. mTORC1/rpS6 and spermatogenic function in the testis-insights from the adjudin model. Reprod Toxicol. 2019 Oct

Subcellular Location

Cytosol, Endoplasmic reticulum, Nucleus.

UNIPROT

SwissProt: P62753 Human

SwissProt: P62754 Mouse

SwissProt: P62755 Rat

Synonyms