PSMB1 Rabbit Polyclonal Antibody (HA500545)

UNIPROT #

P20618

PROTEIN NAME

PSMB1

SYNONYMS

FLJ25321 antibody;HC5 antibody;KIAA1838 antibody;Macropain subunit C5 antibody;Multicatalytic endopeptidase complex subunit C5 antibody;Proteasome (prosome macropain) subunit beta type 1 antibody;Proteasome beta 1 subunit antibody;Proteasome component C5 antibody;Proteasome gamma chain antibody;Proteasome subunit beta type 1 antibody;Proteasome subunit beta type-1 antibody;Proteasome subunit HC5 antibody;PSB1_HUMAN antibody;PSC5 antibody;PSMB 1 antibody;PSMB1 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

Proteasome subunit beta type-1 also known as 20S proteasome subunit beta-6 (based on systematic nomenclature) is a protein that in humans is encoded by the PSMB1 gene. This protein is one of the 17 essential subunits (alpha subunits 1-7, constitutive beta subunits 1-7, and inducible subunits including beta1i, beta2i, beta5i) that contributes to the complete assembly of 20S proteasome complex. In particular, proteasome subunit beta type-1, along with other beta subunits, assemble into two heptameric rings and subsequently a proteolytic chamber for substrate degradation. The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological processes. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.