Inversin Rabbit Polyclonal Antibody

Function

Inversin is a protein that in humans is encoded by the INVS gene. This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Two transcript variants encoding distinct isoforms have been identified for this gene. INVS has been shown to interact with NPHP1.

Background References

1. Solic I et al. Expression Pattern of α-Tubulin, Inversin and Its Target Dishevelled-1 and Morphology of Primary Cilia in Normal Human Kidney Development and Diseases. Int J Mol Sci. 2021 Mar

2. Bennett HW et al. Novel fibrillar structure in the inversin compartment of primary cilia revealed by 3D single-molecule superresolution microscopy.

3. , Gustavsson AK, Bayas CA, Petrov PN, Mooney N, Moerner WE, Jackson PK. Mol Biol Cell. 2020 Mar

Subcellular Location

Cytoplasm, Membrane, Nucleus.

UNIPROT

SwissProt: Q9Y283 Human

SwissProt: O89019 Mouse

Entrez Gene: 313228 Rat

Synonyms

INV antibody

Inversion of embryo turning homolog antibody

inversion of embryonic turning antibody

INVS antibody

Nephrocystin 2 antibody

Nephrocystin-2 antibody

Nephrocystin2 antibody

nephronophthisis 2 (infantile) antibody

NPH2 antibody

NPHP2 antibody