DKK2 Rabbit Polyclonal Antibody

Function

Dickkopf-related protein 2 is a protein in the Dickkopf family that in humans is encoded by the DKK2 gene. This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.

Background References

1. Mamelli RE, Felipe AV, Silva TD, Hinz V, Forones NM. RNAM EXPRESSION AND DNA METHYLATION OF DKK2 GENE IN COLORECTAL CÂNCER. Arq Gastroenterol. 2021 Jan-Mar;58(1):55-60.

2. Zhou B, Peng K, Wang G, Chen W, Liu P, Chen F, Kang Y. miR‑483‑3p promotes the osteogenesis of human osteoblasts by targeting Dikkopf 2 (DKK2) and the Wnt signaling pathway. Int J Mol Med. 2020 Oct;46(4):1571-1581.

Subcellular Location

Protein located outside the cell membrane(s).

UNIPROT

SwissProt: Q9UBU2 Human

SwissProt: Q9QYZ8 Mouse

SwissProt: D3ZN48 Rat

Synonyms

Anti-DKK2 antibody

DKK2 (N70) Antibody

DKK2 Polyclonal Antibody

DKK2 Monoclonal Antibody