Kallikrein 11 Rabbit Polyclonal Antibody
Catalog# HA500216
Kallikrein 11 Rabbit Polyclonal Antibody
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WB
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Human
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Mouse
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unconjugated
Overview
Product Name
Kallikrein 11 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Recombinant protein within human Kallikrein 11 aa 82-282.
Species Reactivity
Human, Mouse
Validated Applications
WB
Target Molecular Weight
predicated 31 kDa
Positive Control
Mouse brain tissue lysate, human skin tissue lysate, K562 cell lysate.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
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WB
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1:500-1:2,000
Target
Function
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing and the use of alternate promoters results in multiple transcript variants encoding distinct isoforms which are differentially expressed.
Background References
1. Li XL. et. al. Diagnostic and prognostic values of KLK11 in nasopharyngeal carcinoma. Eur Rev Med Pharmacol Sci. 2020 Sep
2. He X. et. al. KLK11 suppresses cellular proliferation via inhibition of Wnt/beta-catenin signaling pathway in esophageal squamous cell carcinoma. Am J Cancer Res. 2019 Oct
Subcellular Location
Secreted; Golgi apparatus.
Synonyms
Hippostasin antibody
hK11 antibody
Kallikrein 11 antibody
Kallikrein 11 isoform 1 preproprotein antibody
Kallikrein 11 isoform 2 precursor antibody
Kallikrein 11 precursor antibody
Kallikrein related peptidase 11 antibody
Kallikrein-11 inactive chain 2 antibody
KLK 11 antibody
Klk11 antibody
ExpandImages
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Western blot analysis of Kallikrein 11 on different lysates with Rabbit anti-Kallikrein 11 antibody (HA500216) at 1/2,000 dilution.
Lane 1: HeLa (Human cervical adenocarcinoma cell) cell lysate
Lane 2: Mouse brain tissue lysate
Lane 3: Rat brain tissue lysate
Lysates/proteins at 15 µg/Lane.
Exposure time: 30 seconds; ECL: K1801
Blocking: 5% NFDM/TBST, 1 hour at room temperature
Primary antibody: HA500216, 1/2,000 in primary antibody dilution buffer (K1803), overnight at 4 ℃
Secondary antibody: Goat anti-Rabbit IgG-HRP (HA1001), 1/50,000 in 5% NFDM/TBST, 1 hour at room temperature
Predicted band size: 31 kDa
Observed band size: 48 kDa
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"