PFKFB2 Rabbit Polyclonal Antibody (HA500200)

UNIPROT #

O60825

PROTEIN NAME

PFKFB2

SYNONYMS

6 phosphofructo 2 kinase/fructose 2 6 biphosphatase 2 antibody;6-bisphosphatase antibody;6-P2ase 2 antibody;6-P2ASE heart-type isozyme antibody;6PF 2 K/Fru 2 6 P2ASE heart type isozyme antibody;6PF-2-K/Fru-2 antibody;6PF-2-K/Fru-26-P2ase 2 antibody;6PF-2-K/Fru-26-P2ase heart-type isozyme antibody;F262_HUMAN antibody;Fructose 2 6 bisphosphatase cardiac isozyme antibody;Fructose-2 antibody;PFK 2/FBPase 2 antibody;PFK/FBPase 2 antibody;PFKFB cardiac antibody;PFKFB2 antibody

SUBCELLULAR LOCATION

Cytosol, Nucleoplasm.

FUNCTION

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene.