NR3B Rabbit Polyclonal Antibody
Catalog# HA500134
NR3B Rabbit Polyclonal Antibody
-
WB
-
Human
-
unconjugated
Overview
Product Name
NR3B Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within C-terminal human NR3B(Cytoplasmic domain).
Species Reactivity
Human
Validated Applications
WB
Target Molecular Weight
113 kDa
Positive Control
Daudi cell lysate, 293 cell lysate, THP-1 cell lysate, MCF-7 cell lysate, U937 cell lysate, A549 cell lysate.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
-
WB
-
1:2,000-1:5,000
Target
Function
The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia. NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.
Background References
1. Hornig T. et. al. GRIN3B missense mutation as an inherited risk factor for schizophrenia: whole-exome sequencing in a family with a familiar history of psychotic disorders. Genet Res (Camb). 2017 Jan
2. Lin YT. et. al. A recently-discovered NMDA receptor gene, GRIN3B, is associated with duration mismatch negativity. Psychiatry Res. 2014 Aug
Subcellular Location
Cell membrane, postsynaptic cell membrane.
UNIPROT
Synonyms
GluN3B antibody
Glutamate [NMDA] receptor subunit 3B antibody
Glutamate receptor ionotropic N methyl D aspartate 3B antibody
Glutamate receptor ionotropic NMDA 3B antibody
GRIN3B antibody
N-methyl-D-aspartate receptor subtype 3B antibody
NMD3B_HUMAN antibody
NMDA receptor subunit 3B antibody
NMDA type glutamate receptor subunit NR3B antibody
NMDAR3B antibody
ExpandImages
-
Western blot analysis of NR3B on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (HA500134, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:200,000 dilution was used for 1 hour at room temperature.
Positive control:
Lane 1: Daudi cell lysate
Lane 2: 293 cell lysate
Lane 3: THP-1 cell lysate
Lane 4: MCF-7 cell lysate
Lane 5: U937 cell lysate
Lane 6: A549 cell lysate
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Products with the same target and pathway
