NR3B Rabbit Polyclonal Antibody
Catalog# HA500079
NR3B Rabbit Polyclonal Antibody
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WB
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Human
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unconjugated
Overview
Product Name
NR3B Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within human NR3B aa 179-220 (Extracellular domain).
Species Reactivity
Human
Validated Applications
WB
Molecular Weight
113 kDa
Positive Control
THP-1 cell lysate, 293 cell lysate, Daudi cell lysate.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
-
WB
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1:500-1:2,000
Target
Function
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. The protein encoded by this gene is a subunit of an N-methyl-D-aspartate (NMDA) receptor. The encoded protein is found primarily in motor neurons, where it forms a heterotetramer with GRIN1 to create an excitatory glycine receptor. Variations in this gene have been proposed to be linked to schizophrenia.
Background References
1. Li XY. et. al. Correlations between the level of antibody against peptide of glutamate receptor NR3B subunit in the CSF and cognitive comorbidities of patients with epilepsy. Eur Rev Med Pharmacol Sci. 2019 Jan
2. Hajdú T. et. al. NR1 and NR3B Composed Intranuclear N-methyl-d-aspartate Receptor Complexes in Human Melanoma Cells. Int J Mol Sci. 2018 Jun
Subcellular Location
Cell membrane, postsynaptic cell membrane.
UNIPROT
Synonyms
GluN3B antibody
Glutamate [NMDA] receptor subunit 3B antibody
Glutamate receptor ionotropic N methyl D aspartate 3B antibody
Glutamate receptor ionotropic NMDA 3B antibody
GRIN3B antibody
N-methyl-D-aspartate receptor subtype 3B antibody
NMD3B_HUMAN antibody
NMDA receptor subunit 3B antibody
NMDA type glutamate receptor subunit NR3B antibody
NMDAR3B antibody
ExpandImages
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Western blot analysis of NR3B on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (HA500079, 1/1,000) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:200,000 dilution was used for 1 hour at room temperature.
Positive control:
Lane 1: THP-1 cell lysate
Lane 2: 293 cell lysate
Lane 2: Daudi cell lysate
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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