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EG-VEGF Rabbit Polyclonal Antibody

Usd: 315

Specification

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Catalog# HA500078

EG-VEGF Rabbit Polyclonal Antibody

Application

  • WB

Reactivity

  • Human

  • Mouse

Conjugation

  • unconjugated

Overview

Product Name

EG-VEGF Rabbit Polyclonal Antibody

Antibody Type

Rabbit Polyclonal Antibody

Immunogen

Synthetic peptide within human EG-VEGF aa 41-86.

Species Reactivity

Human, Mouse

Validated Applications

WB

Target Molecular Weight

12 kDa

Positive Control

MCF-7 cell lysate, mouse kidney tissue lysate.

Conjugation

unconjugated

RRID

AB_3071177

Product Features

Form

Liquid

Concentration

1 mg/mL.(The concentration of this product may be batch-dependent)

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Isotype

IgG

Purification Method

Immunogen affinity purified.

Application Dilution

  • WB

  • 1:500-1:2,000

Target

Function

The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner.

Background References

1. Corlan AS. et. al. VEGF, VEGF165b and EG-VEGF expression is specifically related with hormone profile in pituitary adenomas. Eur J Histochem. 2019 Mar

2. Yan X. et. al. EG-VEGF silencing inhibits cell proliferation and promotes cell apoptosis in pancreatic carcinoma via PI3K/AKT/mTOR signaling pathway. Biomed Pharmacother. 2019 Jan

Subcellular Location

Secreted.

UNIPROT

SwissProt: P58294 Human

SwissProt: Q14A28 Mouse

Synonyms

Black mamba toxin related protein antibody

EG VEGF antibody

EG-VEGF antibody

EGVEGF antibody

Endocrine-gland-derived vascular endothelial growth factor antibody

Mambakine antibody

PK1 antibody

PRK1 antibody

PROK1 antibody

PROK1_HUMAN antibody

Expand

Images

  • Western blot analysis of EG-VEGF on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (<a href="/products/HA500078" style="font-weight: bold;text-decoration: underline;">HA500078</a>, 1/1,000) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (<a href="/products/HA1001" style="font-weight: bold;text-decoration: underline;">HA1001</a>) at 1:200,000 dilution was used for 1 hour at room temperature.<br /><span style="font-weight: bold;">Positive control:</span> <br />Lane 1: MCF-7 cell lysate<br />Lane 2: Mouse kidney tissue lysate

    Western blot analysis of EG-VEGF on different lysates. Proteins were transferred to a PVDF membrane and blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (HA500078, 1/1,000) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Rabbit IgG - HRP Secondary Antibody (HA1001) at 1:200,000 dilution was used for 1 hour at room temperature.
    Positive control:
    Lane 1: MCF-7 cell lysate
    Lane 2: Mouse kidney tissue lysate

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"