Cadherin 10 Rabbit Polyclonal Antibody

Function

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients.

Background References

1. Chen CP. et. al. Prenatal diagnosis of a familial 5p14.3-p14.1 deletion encompassing CDH18, CDH12, PMCHL1, PRDM9 and CDH10 in a fetus with congenital heart disease on prenatal ultrasound. Taiwan J Obstet Gynecol. 2018 Oct

2. Jinawath N. et. al. Alterations of type II classical cadherin, cadherin-10 (CDH10), is associated with pancreatic ductal adenocarcinomas. Genes Chromosomes Cancer. 2017 May

Subcellular Location

Cell membrane.

UNIPROT

SwissProt: Q9Y6N8 Human

SwissProt: P70408 Mouse

Entrez Gene: 29181 Rat

Synonyms

CAD10_HUMAN antibody

Cadherin 10 (T2 cadherin) antibody

Cadherin 10 type 2 (T2 cadherin) antibody

Cadherin 10 type 2 antibody

Cadherin-10 antibody

Cadherin10 antibody

CDH10 antibody

T2 cadherin antibody

T2-cadherin antibody