SFRP4 Recombinant Rabbit Monoclonal Antibody [JE41-41]

Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.

Background References

1. Berndt T et al. Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent. J Clin Invest 112:785-794 (2003).

2. Drake J et al. Expression of secreted frizzled-related protein 4 (SFRP4) in primary serous ovarian tumours. Eur J Gynaecol Oncol 30:133-141 (2009).

Sequence Similarity

Belongs to the secreted frizzled-related protein (sFRP) family.

Tissue Specificity

Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, expression levels are inversely correlated with expression of CTNNB1 (at protein level).

Subcellular Location

Secreted.

UNIPROT

SwissProt: Q6FHJ7 Human

SwissProt: Q9Z1N6 Mouse

SwissProt: Q9JLS4 Rat

Synonyms