DDX6 Recombinant Rabbit Monoclonal Antibody [JB41-32]

Function

RCK, also known as DDX6 and P54, is a member of the DEAD-box RNA helicase family of proteins, all of which share common protein motifs. Found in most tissues, RCK is an unwindase that exhibits ATP-dependent RNA un-winding activity, as well as the ability to decay RNA in the 5'-3' direction. In non-malignant cells, RCK is associated with all processes of normal RNA metabolism including splicing, export and translation initiation. Mutations in the gene encoding RCK can cause the protein to be overexpressed, changing its function to that of an oncogene that positively regulates the expression of genes involved in cell growth and proliferation. It is believed that, through its unwindase activity, the main function of RCK is to downregulate mRNA expression and maintain normal transcriptional levels within the cell.

Background References

1. Fenger-Groen M et al. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Mol Cell 20:905-915 (2005).

2. Hu G et al. A conserved mechanism of TOR-dependent RCK-mediated mRNA degradation regulates autophagy. Nat Cell Biol 17:930-942 (2015).

Sequence Similarity

Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.

Tissue Specificity

Abundantly expressed in most tissues.

Post-translational Modification

Sumoylated.

Subcellular Location

Cytoplasm. Nucleus.

UNIPROT

SwissProt: P26196 Human

SwissProt: P54823 Mouse

Synonyms