GIT1 Recombinant Rabbit Monoclonal Antibody [JU33-39] (ET7106-91)

UNIPROT #

Q9Y2X7

PROTEIN NAME

GIT1

SYNONYMS

ARF GAP GIT1 antibody;ARF GTPase activating protein GIT1 antibody;ARF GTPase-activating protein GIT1 antibody;CAT 1 antibody;CAT-1 antibody;CaT1 antibody;Cool associated and tyrosine phosphorylated protein 1 antibody;Cool-associated and tyrosine-phosphorylated protein 1 antibody;G protein coupled receptor kinase interacting ArfGAP 1 antibody;G protein coupled receptor kinase interactor 1 antibody;G protein-coupled receptor kinase-interactor 1 antibody;GIT1 antibody;GIT1_HUMAN antibody;GRK interacting protein 1 antibody;GRK-interacting protein 1 antibody

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on tyrosine residues by PTK2/FAK1 and SRC in growing fibroblasts. Tyrosine-phosphorylation is increased following cell spreading on fibronectin, decreased in cells arrested in mitosis and increased in the ensuing G1 phase (By similarity).

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist. G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade. GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking. GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling.