PKA 2 beta (regulatory subunit) Recombinant Rabbit Monoclonal Antibody [JA11-69] (ET1704-15)

UNIPROT #

P31323

PROTEIN NAME

PKA 2 beta (regulatory subunit)

SYNONYMS

AI451071 antibody;AW061005 antibody;cAMP dependent protein kinase type II beta regulatory chain antibody;cAMP dependent protein kinase type II beta regulatory subunit antibody;cAMP-dependent protein kinase type II-beta regulatory subunit antibody;H RG363E19.2 antibody;KAP3_HUMAN antibody;MGC116401 antibody;Pkarb2 antibody;PRKAR 2 antibody;PRKAR2 antibody;PRKAR2B antibody;Protein kinase cAMP dependent regulatory type II beta antibody;RATDNA antibody;RII beta antibody;RII(beta) antibody;RIIbeta antibody;WUGSC:H RG363E19.2 antibody

SEQUENCE SIMILARITIES

Belongs to the cAMP-dependent kinase regulatory chain family.

TISSUE SPECIFICITY

Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by the activated catalytic chain.

SUBCELLULAR LOCATION

Cytoplasm. Cell membrane.

FUNCTION

The second messenger cyclic AMP mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. One of several regulatory subunits, p-PKA IIβ reg (cAMP-dependent protein kinase type II-beta regulatory subunit), also known as PRKAR2B, is a 418 amino acid protein that is phosphorylated by the activated catalytic chain. p-PKA IIβ reg knockout mice exhibit diminished white adipose tissue and were protected against diet-induced obesity and fatty livers,as well as markedly reduced leptin mRNA. Also playing a role in the immune response, p-PKA IIβ reg suppresses CREB transcriptional activity and down-regulates IL-2 production in T-lymphocytes.