Thymidine Kinase 1 Recombinant Rabbit Monoclonal Antibody [JF0970] (ET1702-31)

UNIPROT #

P04183

PROTEIN NAME

Thymidine Kinase 1

SYNONYMS

cytosolic antibody;KITH_HUMAN antibody;Thymidine kinase 1 antibody;Thymidine kinase 1 soluble antibody;Thymidine kinase 1 soluble isoform antibody;Thymidine kinase antibody;Thymidine kinase cytosolic antibody;TK 1 antibody;TK 2 antibody;TK1 antibody;Tk1a antibody;Tk1b antibody;TK2 antibody

SEQUENCE SIMILARITIES

Belongs to the thymidine kinase family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated on Ser-13 in mitosis.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Thymidine Kinase (TK1) is a highly conserved phosphotransferase that is present in most living cells. Thymidine Kinase catalyzes the phosphorylation reaction: deoxythymidine + ATP = deoxythymidine 5'-phosphate + ADP; it is thus involved in the reaction chain to introduce deoxythymidine into the DNA. Thymidine kinase is required for the action of many antiviral drugs, such as azidothymidine (AZT), and is is also used to select hybridoma cell lines in the production of monoclonal antibodies. Thymidine Kinase has many clinical applications as it is only present in anticipation of cell division. Because of this, Thymidine Kinase can be used as a proliferation marker in the diagnosis, treatment, and follow-up of malignant diseases, especially hematological malignancies. Thymidine Kinase may be observed as a monomer, dimer, trimer or tetramer.