Collagen X Recombinant Rabbit Monoclonal Antibody [JF0961]

Function

Collagen Type X is associated with hypertrophic chondrocytes of avian and mammalian growth plate tissues during the endochondral growth of long bones. It is a component of normal articular cartilage in adult human, growing pig and newborn rat, and it is also present during any disruption of normal metabolic status of articular cartilage that occur with osteoarthritis. Collagen Type X is composed of three identical a 1(X) chains, each containing a triple-helical region flanked by a short N-terminal sequence and a larger non-collagenous C-terminal (NC1) domain. Mutations in COL10A1, the gene encoding for Collagen Type X, are associated with metaphyseal dysplasia type Schmid (SMCD) and other related forms of metaphyseal dysplasia. SMCD is characterized by short-limbed dwarfism, an outward "flaring" of the lower rib cage, bowed legs, leg pain and a hip deformity that causes the thigh bone to angle toward the center of the body.

Background References

1. Bian Q et al. Excessive Activation of TGF by Spinal Instability Causes Vertebral Endplate Sclerosis. Sci Rep 6:27093 (2016).

2. Xu X et al. Aberrant Activation of TGF- in Subchondral Bone at the Onset of Rheumatoid Arthritis Joint Destruction. J Bone Miner Res 30:2033-43 (2015).

Post-translational Modification

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Subcellular Location

Secreted, extracellular space, extracellular matrix.

UNIPROT

SwissProt: Q03692 Human

SwissProt: Q05306 Mouse

Unigene:20579 Rat

Synonyms