Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890] (ET1701-53)

UNIPROT #

Q92851

PROTEIN NAME

Caspase-10

SYNONYMS

Caspase10;ALPS2 antibody;Apoptotic protease Mch-4 antibody;CASP 10 antibody;CASP-10 antibody;CASP10 antibody;CASPA_HUMAN antibody;Caspase 10 apoptosis related cysteine peptidase antibody;Caspase-10 subunit p12 antibody;FADD like ICE2 antibody;Fas associated death domain protein antibody;FAS-associated death domain protein interleukin-1B-converting enzyme 2 antibody;FLICE 2 antibody;FLICE2 antibody;ICE like apoptotic protease 4 antibody;ICE-like apoptotic protease 4 antibody;Interleukin 1B converting enzyme 2 antibody;MCH 4 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase C14A family.

TISSUE SPECIFICITY

Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.

POST-TRANSLATIONAL MODIFICATION

Cleavage by granzyme B and autocatalytic activity generate the two active subunits.

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

Caspase-10, also designated Mch4, is recruited to the native TRAIL and CD9 death-inducing signaling complexes (DISCs) by the FADD/Mort1 adaptor protein complex. Caspase-10 requires the assembly of the FADD and DISC complexes for its recruitment and cleavage-induced activation during CD95-induced apoptosis of activated T cells. The N-terminus of caspase-10 contains FADD-like death effector domains further indicating that it associates with FADD to induce apoptosis. Caspase-10 is not required for apoptosis induction and when overexpressed, cannot reverse defects in apoptosis induction caused by caspase-8 deficiency. Granzyme B cleaves procaspase-10 at an IXXD-A processing sequence to produce mature caspase-10. Mutations in the caspase-10 gene in the prodomain, p17 large protease subunit and p12 small protease subunit have been linked to a number of non-Hodgkin lymphomas in humans.