Acetyl-CoA Carboxylase 1 (ACC1) Recombinant Rabbit Monoclonal Antibody [ST53-08] (ET1609-77)

UNIPROT #

Q13085

PROTEIN NAME

Acetyl-CoA Carboxylase 1 (ACC1)

SYNONYMS

ACAC antibody;ACACA antibody;ACACA_HUMAN antibody;ACC alpha antibody;ACC antibody;ACC-alpha antibody;ACC1 antibody;ACCA antibody;Acetyl CoA carboxylase 1 antibody;Acetyl CoA carboxylase alpha antibody;Acetyl Coenzyme A carboxylase alpha antibody;Biotin carboxylase antibody;COA1 antibody;COA2 antibody;HACC275 antibody;OTTHUMP00000164069 antibody;OTTHUMP00000164070 antibody;OTTHUMP00000164076 antibody;OTTHUMP00000240532 antibody

TISSUE SPECIFICITY

Expressed in brain, placenta, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Ser-1263 is required for interaction with BRCA1.; Phosphorylation at Ser-80 by AMPK inactivates enzyme activity.; The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. ACCα (ACC1) is the rate-limiting enzyme in the biogenesis of long-chain fatty acids, and ACCβ (ACC2) may control mitochondrial fatty acid oxidation. These two isoforms of ACC control the amount of fatty acids in the cells. The catalytic function of ACCα is regulated by phosphorylation (inactive) and dephosphorylation (active) of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA, which serve as the enzyme’s short-term regulatory mechanism. The gene encoding ACCα maps to human chromosome 17 and encodes a form of ACC, which is the major ACC in lipogenic tissues. The catalytic core of ACCβ is homologous to that of the ACCα, except for an additional peptide of about 150 amino acids at the N-terminus.