Rab4A Recombinant Rabbit Monoclonal Antibody [SR27-08]

Function

The Ras-related superfamily of guanine nucleotide binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab superfamilies, exhibits 30-60% homology with Ras p21. Accumulating data suggests an important role for Rab proteins, either in endocytosis or in biosynthetic protein transport. The transport of newly synthesized proteins from the endoplasmic reticulum to various stacks of the Golgi complex and to secretory vesicles involves at each stage the movement of carrier vesicles, a process that appears to involve Rab protein function. The possiblity that Rab proteins might also direct the exocytosis from secretory vesicles to the plasma membrane is supported by the observation that in yeast, the SEC4 protein, which is 40% homologous to Rab proteins, is associated with secretory vesicles. At least eight members of the Rab family have been identified, each of which is found at a particular stage of a membrane transport pathway.

Background References

1. Finetti F et al. Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system. J Cell Sci 127:1924-37 (2014).

2. Peng C et al. Ablation of vacuole protein sorting 18 (vps18) gene leads to neurodegeneration and impaired neuronal migration by disrupting multiple vesicle transport pathways to lysosomes. J Biol Chem 287:32861-73 (2012).

Sequence Similarity

Belongs to the small GTPase superfamily. Rab family.

Post-translational Modification

Phosphorylated by CDK1 kinase during mitosis.

Subcellular Location

Cytoplasm, Membrane

UNIPROT

SwissProt: P20338 Human

SwissProt: P56371 Mouse

SwissProt: P05714 Rat

Synonyms