CLIC1 Rabbit Polyclonal Antibody (ER2001-32)

UNIPROT #

O00299

PROTEIN NAME

CLIC1

SYNONYMS

Chloride channel ABP antibody;Chloride intracellular channel 1 antibody;Chloride intracellular channel protein 1 antibody;CLIC 1 antibody;CLIC1 antibody;CLIC1_HUMAN antibody;G6 antibody;hRNCC antibody;NCC 27 antibody;NCC27 antibody;Nuclear chloride ion channel 27 antibody;Nuclear chloride ion channel protein antibody;p64CLCP antibody;Regulatory nuclear chloride ion channel protein antibody;RNCC protein antibody

SUBCELLULAR LOCATION

Cell membrane, Cytoplasm, Membrane, Nucleus.

FUNCTION

Chloride intracellular channel protein 1 is a protein that in humans is encoded by the CLIC1 gene. Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle. Mainly cytoplasmic expression in most glandular epithelial cells, also membranous expression in renal tubules. CLIC1 is frequently upregulated in multiple human malignancies and has been demonstrated to play a critical role in cell proliferation, apoptosis, and invasion. However, limited is known about its expression, biological functions, and action mechanism in oral malignancies.