GLUD1 Rabbit Polyclonal Antibody (ER1902-85)

UNIPROT #

P00367

PROTEIN NAME

GLUD1

SYNONYMS

AI118167 antibody;DHE3_HUMAN antibody;EC 1.4.1.3 antibody;GDH 1 antibody;GDH antibody;Gdh-X antibody;GDH1 antibody;GLUD antibody;Glud1 antibody;Glud1a antibody;Glud1b antibody;Gludl antibody;Glutamate dehydrogenase (NAD(P)+) antibody;Glutamate dehydrogenase 1 antibody;Glutamate dehydrogenase 1 mitochondrial antibody;Glutamate dehydrogenase 1a antibody;Glutamate dehydrogenase 1b antibody;Memory-related gene 2 protein antibody;MGC127177 antibody;MGC132003 antibody;MGC80801 antibody;MGC93608 antibody;mitochondrial antibody;MRG-2 antibody

SEQUENCE SIMILARITIES

Belongs to the Glu/Leu/Phe/Val dehydrogenases family.

POST-TRANSLATIONAL MODIFICATION

ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity (By similarity). Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer.

SUBCELLULAR LOCATION

Mitochondrion matrix.

FUNCTION

This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X.