SLFN12 Rabbit Polyclonal Antibody (ER1902-84)

UNIPROT #

Q8IYM2

PROTEIN NAME

SLFN12

SYNONYMS

FLJ10260 antibody;Schlafen family member 12 antibody;schlafen family member12 antibody;SLFN12 antibody;SLFN3 antibody;SLN12_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the Schlafen family. Subgroup II subfamily.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Schlafen family members are preferentially expressed in lymphoid tissues and are differentially regulated during thymocyte maturation. Schlafen proteins function as suppressors of cell growth and are thought to play a role in the maintenance of T cell quiescence. All members of the Schlafen family contain a conserved core domain and are substantially diversified at the N terminus. The prototype member of the Schlafen family, Slfn1, is transcriptionally unregulated during thymocyte positive selection and its induction leads to G0/G1 arrest, suggesting that Slfn1 participates in the regulation of cell cycle and potentially acts as a determining factor for apoptosis. Slfn1 and Slfn2 are both unregulated during the double-positive (DP) and single-positive (SP) stages of thymocyte development, whereas Slfn4 is down regulated at these stages. Changes in Schalfen protein expression may contribute to phenotypic differences seen in thymic subsets. Slfn12 (schlafen family member 12), also known as SLFN3, is a 578 amino acid protein belonging to the Schlafen family.