LGR5 Rabbit Polyclonal Antibody (ER1902-52)

UNIPROT #

O75473

PROTEIN NAME

LGR5/GPR49

SYNONYMS

FEX antibody;G protein coupled receptor 49 antibody;G protein coupled receptor 67 antibody;g protein-coupled receptor fex antibody;G-protein coupled receptor 49 antibody;G-protein coupled receptor 67 antibody;G-protein coupled receptor HG38 antibody;GPCR GPR49 antibody;GPR 49 antibody;GPR 67 antibody;GPR49 antibody;GPR67 antibody;GRP 49 antibody;GRP49 antibody;HG 38 antibody;HG38 antibody;Leucine rich repeat containing G protein coupled receptor 5 antibody;Leucine-rich repeat-containing G-protein coupled receptor 5 antibody;LGR 5 antibody;LGR5 antibody;LGR5_HUMAN antibody;MGC117008 antibody;Orphan G protein coupled receptor HG38 antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.

SUBCELLULAR LOCATION

Cell membrane, Golgi apparatus.

FUNCTION

G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors or heptahelical receptors, interact with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers, such as diacylglycerol, cyclic AMP, inositol phosphates and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. LGR5 (leucine-rich repeat-containing G-protein coupled receptor 5), also known as GPR49 or GPR67, is a 907 amino acid multi-pass membrane protein that contains 17 leucine-rich repeats and belongs to the G protein-coupled receptor family. Expressed in placenta, skeletal muscle and spinal cord, LGR5 functions as an orphan receptor that is thought to play an important role in embryonic growth control and cellular differentiation. Overexpression of LGR5 is associated with increased tumor susceptibility and malignant transformation, implicating LGR5 as a potent tumor-inducing protein.