Kv1.4 Rabbit Polyclonal Antibody (ER1902-49)

UNIPROT #

P22459

PROTEIN NAME

Kv1.4

SYNONYMS

Voltage gated K+ channel HuKII antibody;Fetal skeletal muscle potassium channel antibody;HBK4 antibody;HK1 antibody;HPCN2 antibody;HUKII antibody;Kcna4 antibody;KCNA4_HUMAN antibody;KCNA4L antibody;KCNA8 antibody;kv1.4 antibody;PCN2 antibody;Potassium channel 2 antibody;Potassium voltage gated channel shaker related subfamily member 4 antibody;Potassium voltage gated channel subfamily A member 4 antibody;Potassium voltage-gated channel subfamily A member 4 antibody;Rapidly inactivating potassium channel antibody;Shaker related potassium channel Kv1.4 antibody;Type A potassium channel antibody;Voltage gated potassium channel HBK4 antibody;Voltage gated potassium channel HK1 antibody;Voltage gated potassium channel subunit Kv1.4 antibody;Voltage-gated K(+) channel HuKII antibody;Voltage-gated potassium channel HBK4 antibody;Voltage-gated potassium channel HK1 antibody;Voltage-gated potassium channel subunit Kv1.4 antibody

SEQUENCE SIMILARITIES

Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.4/KCNA4 sub-subfamily.

TISSUE SPECIFICITY

Expressed in brain, and at lower levels in the testis, lung, kidney, colon and heart. Detected in heart ventricle.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure . Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation .