CXCL12/SDF1 Rabbit Polyclonal Antibody (ER1902-35)

UNIPROT #

P48061

PROTEIN NAME

SDF1

SYNONYMS

12-O-tetradecanoylphorbol 13-acetate repressed protein 1 antibody;AI174028 antibody;C-X-C motif chemokine 12 antibody;Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) antibody;Chemokine (C-X-C motif) ligand 12 antibody;Chemokine CXC motif ligand 12 antibody;cxcl12 antibody;hIRH antibody;hSDF-1 antibody;Intercrine reduced in hepatomas antibody;IRH antibody;OTTHUMP00000019491 antibody;PBSF antibody;Pre-B cell growth-stimulating factor antibody;SCYB12 antibody;SDF 1 antibody;SDF-1 antibody;SDF-1-alpha(3-67) antibody;SDF-1a antibody;SDF-1b antibody;SDF1_HUMAN antibody;SDF1A antibody;SDF1B antibody;Stromal cell-derived factor 1 antibody;Stromal cell-derived factor 1 delta antibody;Stromal cell-derived factor 1 gamma antibody;Stromal cell-derived factor 1a antibody;Stromal cell-derived factor-1 alpha antibody;Thymic lymphoma cell-stimulating factor antibody;Tlsf antibody;TLSF-a antibody;TLSF-b antibody;Tlsfa antibody;Tlsfb antibody;TPAR1 antibody

SEQUENCE SIMILARITIES

Belongs to the intercrine alpha (chemokine CxC) family.

TISSUE SPECIFICITY

Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.

DEVELOPMENTAL STAGE

Isoform Alpha is ubiquitously expressed in fetal tissues. Isoform Beta and isoform Delta have more limited expression patterns, with highest levels detected in fetal spleen and fetal liver, respectively. Isoform Gamma and isoform Theta are weakly detected in fetal kidney.

POST-TRANSLATIONAL MODIFICATION

Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner . Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.