DPP6 Rabbit Polyclonal Antibody (ER1902-07)

UNIPROT #

P42658

PROTEIN NAME

DPP6

SYNONYMS

Dipeptidyl aminopeptidase IV related protein antibody;Dipeptidyl aminopeptidase like protein 6 antibody;Dipeptidyl aminopeptidase related protein antibody;Dipeptidyl peptidase 6 antibody;Dipeptidyl peptidase IV like protein antibody;Dipeptidyl peptidase IV related protein antibody;Dipeptidylpeptidase 6 antibody;Dipeptidylpeptidase VI antibody;DPP VI antibody;DPPX antibody;VF2 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase S9B family.

TISSUE SPECIFICITY

Expressed predominantly in brain.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Promotes cell surface expression of the potassium channel KCND2 . Modulates the activity and gating characteristics of the potassium channel KCND2. Has no dipeptidyl aminopeptidase activity .This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.