AKT1/2/3 Rabbit Polyclonal Antibody (ER1901-33)

UNIPROT #

Q9Y243

PROTEIN NAME

AKT3

SYNONYMS

Akt3 antibody;AKT3 kinase antibody;AKT3_HUMAN antibody;DKFZp434N0250 antibody;MPPH antibody;PKB gamma antibody;PKBG antibody;PRKBG antibody;Protein kinase Akt-3 antibody;Protein Kinase AKT3 antibody;Protein kinase B gamma antibody;RAC gamma antibody;RAC gamma serine/threonine protein kinase antibody;RAC-gamma serine/threonine-protein kinase antibody;RAC-PK-gamma antibody;RACPK Gamma antibody;Serine threonine protein kinase Akt 3 antibody;Serine threonine protein kinase Akt3 antibody;STK 2 antibody;STK-2 antibody;STK2 antibody;V akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) antibody;V akt murine thymoma viral oncogene homolog 3 antibody;V akt murine thymoma viral oncogene homolog 3 protein kinase B gamma antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.

TISSUE SPECIFICITY

In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation on Thr-305 and Ser-472 is required for full activity.; Ubiquitinated. When fully phosphorylated and translocated into the nucleus, undergoes 'Lys-48'-polyubiquitination catalyzed by TTC3, leading to its degradation by the proteasome.; O-GlcNAcylation at Thr-302 and Thr-309 inhibits activating phosphorylation at Thr-305 via disrupting the interaction between AKT and PDK1.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Membrane.

FUNCTION

AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis.