TMEM16A Rabbit Polyclonal Antibody (ER1901-30)
Catalog# ER1901-30
Rabbit Polyclonal to DOG1
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WB
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IF-Cell
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IHC-P
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FC
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Human
Specifications
Product Type
Rabbit polyclonal primary
Product Name
TMEM16A Rabbit Polyclonal Antibody (ER1901-30)
Immunogen
Synthetic peptide within c-terminal human tmem16a.
Host
Rabbit
Positive Control
PC-3M cell lysates, A549, HepG2, human liver carcinoma tissue, human seminal pouch tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB:1:500-1:1000
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IF-Cell:1:50-1:200
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IHC-P:1:50-1:200
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FC:1:50-1:100
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
114/97 kDa (Predicted band size)
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
DOG1
SYNONYMS
ANO 1 antibody;ANO1 antibody;ANO1_HUMAN antibody;Anoctamin 1 antibody;Anoctamin 1 calcium activated chloride channel antibody;Anoctamin-1 antibody;Anoctamin1 antibody;Ca2+ activated Cl- channel antibody;Calcium Activated Chloride Channel antibody;Discovered on gastrointestinal stromal tumors protein 1 antibody;DOG 1 antibody;DOG1 antibody;FLJ10261 antibody;Membrane protein antibody;Oral cancer overexpressed 2 antibody;Oral cancer overexpressed protein 2 antibody;ORAOV 2 antibody;ORAOV2 antibody;TAOS 2 antibody;TAOS2 antibody;TMEM 16A antibody;TMEM16A antibody;Transmembrane protein 16A (eight membrane spanning domains) antibody;Transmembrane protein 16A antibody;Tumor amplified and overexpressed sequence 2 antibody;Tumor-amplified and overexpressed sequence 2 antibody
SEQUENCE SIMILARITIES
Belongs to the anoctamin family.
TISSUE SPECIFICITY
Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.
SUBCELLULAR LOCATION
Cell membrane, cytoplasm.
FUNCTION
ANO1 (anoctamin 1), also known as DOG1, ORAOV2, TAOS2 or TMEM16A, is a 986 amino acid multi-pass membrane protein that localizes to both the cell membrane and the cytoplasm and belongs to the anoctamin family. Expressed in a variety of tissues with highest expression in liver, gastrointestinal muscle and skeletal muscle, ANO1 functions as a calcium-activated chloride channel that is required for normal tracheal development. Human ANO1 shares 90% sequence identity with its mouse counterpart, suggesting a conserved role between species. ANO1 is present in breast, pancreatic, gastric, and uterine cancers, as well as in neck, ovarian and parathyroid tumors, suggesting a role for ANO1 in carcinogenesis. Three isoforms of ANO1 exist due to alternative splicing events.
CITATIONS
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Wei-Tong-Xin ameliorated cisplatin-induced mitophagy and apoptosis in gastric antral mucosa by activating the Nrf2/HO-1 pathway
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WB
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Mouse
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Citation
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