SSRP1 Rabbit Polyclonal Antibody (ER1901-13)

UNIPROT #

Q08945

PROTEIN NAME

SSRP1

SYNONYMS

Chromatin-specific transcription elongation factor 80 kDa subunit antibody;Cisplatin DNA SSRP antibody;Facilitates chromatin remodeling 80 kDa subunit antibody;Facilitates chromatin transcription complex 80 kDa subunit antibody;Facilitates chromatin transcription complex subunit SSRP1 antibody;FACT 80 kDa subunit antibody;FACT complex subunit SSRP1 antibody;FACT80 antibody;FACTp80 antibody;hSSRP1 antibody;Recombination signal sequence recognition protein 1 antibody;Recombination signal sequence recognition protein antibody;SSRP 1 antibody;SSRP1 antibody;SSRP1_HUMAN antibody;Structure specific recognition protein 1 antibody;Structure-specific recognition protein 1 antibody;T160 antibody

SEQUENCE SIMILARITIES

Belongs to the SSRP1 family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CK2 following UV but not gamma irradiation. Phosphorylation inhibits its DNA-binding activity.; Ubiquitinated. Polyubiquitinated following caspase cleavage resulting in degradation of the N-terminal ubiquitinated part of the cleaved protein.; Sumoylated.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.