Galectin 3 Rabbit Polyclonal Antibody (ER1803-82)
Catalog# ER1803-82
Rabbit Polyclonal to Galectin 3
-
WB
-
IF-Cell
-
IHC-P
-
FC
-
Human
-
Mouse
-
Rat
Positive control:
Lane 1: SiHa cell lysate
Lane 2: Mouse colon tissue lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
Galectin 3 Rabbit Polyclonal Antibody (ER1803-82)
Immunogen
Recombinant protein within human galectin 3 aa 1-180.
Host
Rabbit
Positive Control
SiHa, mouse colon tissue, A431, LOVO, rat lung tissue, human colon cancer tissue, mouse testis tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
-
WB:1:500
-
IF-Cell:1:50-1:200
-
IHC-P:1:50-1:200
-
FC:1:50-1:100
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
26 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
Galectin 3
SYNONYMS
35 kDa lectin antibody;Carbohydrate binding protein 35 antibody;Carbohydrate-binding protein 35 antibody;CBP 35 antibody;CBP35 antibody;Gal-3 antibody;GAL3 antibody;Galactose-specific lectin 3 antibody;Galactoside-binding protein antibody;GALBP antibody;Galectin 3 internal gene,included antibody;Galectin-3 antibody;Galectin3 antibody;GALIG antibody;GBP antibody;IgE binding protein antibody;IgE-binding protein antibody;L 31 antibody;L 34 antibody;L-31 antibody;L-34 galactoside-binding lectin antibody;L31 antibody;Laminin-binding protein antibody;Lectin L-29 antibody;Lectin, galactose binding, soluble 3 antibody;LEG3_HUMAN antibody;LGALS2 antibody;LGALS3 antibody;MAC 2 antigen antibody;Mac-2 antibody;Mac-2 antigen antibody;MAC2 antibody;Macrophage galactose-specific lectin antibody;MGC105387 antibody
TISSUE SPECIFICITY
A major expression is found in the colonic epithelium. It is also abundant in the activated macrophages. Expressed in fetal membranes.
SUBCELLULAR LOCATION
Cytoplasm, Nucleus, Secreted.
FUNCTION
Galectins are a family of soluble b-galactoside-binding animal lectins that modulate cell-to-cell adhesion and cell-to-extracellular matrix (ECM) inter- actions and play a role in tumor progression, pre-mRNA splicing and apop-tosis. The galectin-3 protein, also known as Mac-2, hMac-2, GALBP, CBP35 or LGALS3, contains a single carbohydrate binding domain, which binds galactose-containing glycoconjugates. Galectin-3 is expressed in colonic and intestinal epithelium, inflammatory macrophages, papillary and follicular carcinomas, neoplastic astrocytes and some B and T lymphocytes. Upregulated expression of galectin-3 is involved in cancer progression and metastasis. Galectin-3 mediates the endocytosis of β1 Integrins in a lactose-dependent manner and is associated with thyroid malignancy and Crohn's disease. It may also be used as a marker for diagnosing cases involving Hurthle cell adenomas and carcinomas.
CITATIONS
-
Li, J., Mao, Y. S., Chen, F., Xia, D. X., & Zhao, T. Q.
Palmitic acid up regulates Gal-3 and induces insulin resistance in macrophages by mediating the balance between KLF4 and NF-κB
