CD99 Rabbit Polyclonal Antibody (ER1803-81)

UNIPROT #

P14209

PROTEIN NAME

CD99

SYNONYMS

12E7 antibody;Antigen identified by monoclonal 12E7, Y homolog antibody;Antigen identified by monoclonal antibodies 12E7, F21 and O13 antibody;CD99 antibody;CD99 antigen antibody;CD99 molecule antibody;CD99_HUMAN antibody;Cell surface antigen 12E7 antibody;Cell surface antigen HBA 71 antibody;Cell surface antigen O13 antibody;E2 antigen antibody;HBA71 antibody;MIC 2X antibody;MIC 2Y antibody;MIC2 (monoclonal antibody 12E7) antibody;MIC2 antibody;MIC2X antibody;MIC2Y antibody;MSK5X antibody;Protein MIC2 antibody;Surface antigen MIC2 antibody;T cell surface glycoprotein E2 antibody;T-cell surface glycoprotein E2 antibody

SEQUENCE SIMILARITIES

Belongs to the CD99 family.

POST-TRANSLATIONAL MODIFICATION

Extensively O-glycosylated.

SUBCELLULAR LOCATION

Membrane.

FUNCTION

MIC2, also designated CD99, is a T cell surface protein that is involved in the aggregation of lymphocytes. Two forms of MIC2, which are differentially expressed, are produced by alternative splicing. The major form induces cellular adhesion, whereas the truncated form inhibits the adhesion process. MIC2 regulates the LFA-1/ICAM-1-mediated adhesion of lymphocytes. Overexpression of the truncated form results in downregulated expression of LFA-1. Cells with downregulated MIC2 exhibit a Hodgkin's and Reed-Sternberg (H-RS) phenotype, indicating that MIC2 plays an important role in regulating cell function and morphology.