Cytokeratin 19 Rabbit Polyclonal Antibody (ER1803-79)

UNIPROT #

P08727

PROTEIN NAME

Cytokeratin 19

SYNONYMS

40 kDa keratin intermediate filament antibody;CK 19 antibody;CK-19 antibody;CK19 antibody;Cytokeratin 19 antibody;Cytokeratin-19 antibody;K19 antibody;K1C19_HUMAN antibody;K1CS antibody;Keratin 19 antibody;Keratin type I 40 kD antibody;Keratin type I 40kD antibody;Keratin type I cytoskeletal 19 antibody;Keratin, type I cytoskeletal 19 antibody;Keratin, type I, 40 kd antibody;Keratin-19 antibody;KRT19 antibody;MGC15366 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.

DEVELOPMENTAL STAGE

Present in hair follicles at all stages of development.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells and have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. For example, many types of cancer cells express Cytokeratin 19 (CK19), an epithelial cytoskeletal protein within the suprabasal squamous epithelium. Cytokeratin 19 is a specific marker of moderate to severe dysplasia and carcinoma in situ in oral cavity squamous epithelium, and measurement of Cytokeratin 19 may be a useful marker in diagnosing hepatoma. Cytokeratin 19 fragment levels in serum have been documented as a marker for lung cancer. Clinical investigations have suggested that serum CYFRA 21-1, a fragment of Cytokeratin 19, may be among the most useful tumor markers.