CTDSPL Rabbit Polyclonal Antibody
Catalog# ER1803-59
CTDSPL Rabbit Polyclonal Antibody
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WB
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FC
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Human
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Mouse
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Rat
Predicted species support after-sales service
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unconjugated
Overview
Product Name
CTDSPL Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Recombinant protein within Human CTDSPL aa 77-252 / 276.
Species Reactivity
Human (Predicted: Mouse, Rat)
Predicted species support after-sales service
Validated Applications
WB, FC
Molecular Weight
Predicted band size: 31 kDa
Positive Control
HepG2 cell lysate, HepG2.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
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WB
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1:500
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FC
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1:50-1:100
Target
Function
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
Background References
1. Yeo M et al. A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5. J Biol Chem 278:26078-26085(2003).
2. Yeo M et al. Small CTD phosphatases function in silencing neuronal gene expression. Science 307:596-600(2005).
Tissue Specificity
Expression is restricted to non-neuronal tissues.
Subcellular Location
Nucleus.
Synonyms
C3orf8 antibody
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3 antibody
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like antibody
CTD small phosphatase-like protein antibody
CTDSL_HUMAN antibody
CTDSP-like antibody
Ctdspl antibody
hYA22 antibody
N-like protein antibody
NIF-like protein antibody
ExpandImages
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Western blot analysis of CTDSPL on HepG2 cell lysate using anti-CTDSPL antibody at 1/500 dilution.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"