Hemagglutinin-neuraminidase Rabbit Polyclonal Antibody
Catalog# ER1803-50
Hemagglutinin-neuraminidase Rabbit Polyclonal Antibody
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WB
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ELISA
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Avian avulavirus 1
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unconjugated
Overview
Product Name
Hemagglutinin-neuraminidase Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within newcastle disease virus Hemagglutinin-neuraminidase aa 206-255 / 586.
Species Reactivity
Avian avulavirus 1
Validated Applications
WB, ELISA
Molecular Weight
Predicted band size: 64 kDa
Positive Control
Hemagglutinin-neuraminidase transfected HEK293 cell.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
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WB
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1:500-1,000
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ELISA
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1:5,000-1:10,000
Target
Function
Hemagglutinin-neuraminidase refers to a single viral protein that has both hemagglutinin and neuraminidase activity. This is in contrast to the proteins found in influenza, where both functions exist but in two separate proteins. However it does show a structural similarity to influenza viral neuraminidase and has a six-bladed beta-propeller structure. Hemagglutinin-neuraminidase allows the virus to stick to a potential host cell, and cut itself loose if necessary. Hemagglutinin-neuraminidase can be found in a variety of paramyxoviruses including mumps virus, human parainfluenza virus 3, and the avian pathogen Newcastle disease virus.
Background References
1. Zaitsev V et al. Second sialic acid binding site in Newcastle disease virus hemagglutinin-neuraminidase: implications for fusion. J Virol. 2004 Apr;78(7):3733-41.
2. Lawrence MC et al. Structure of the haemagglutinin-neuraminidase from human parainfluenza virus type III. J Mol Biol. 2004 Jan 30;335(5):1343-57.
Sequence Similarity
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.
Subcellular Location
Virion membrane.
Images
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☑ Cell treatment (CT)
Western blot analysis of Hemagglutinin Neuraminidase on Hemagglutinin Neuraminidase transfected HEK293 cell lysates using anti- Hemagglutinin Neuraminidase antibody at 1/500 dilution.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"