CaV2.3 Rabbit Polyclonal Antibody
Catalog# ER1803-47
CaV2.3 Rabbit Polyclonal Antibody
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WB
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IF-Cell
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IHC-P
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FC
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Human
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Mouse
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Rat
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unconjugated
Overview
Product Name
CaV2.3 Rabbit Polyclonal Antibody
Antibody Type
Rabbit Polyclonal Antibody
Immunogen
Synthetic peptide within rat CaV23 aa 875-924 / 2,222.
Species Reactivity
Human, Mouse, Rat
Validated Applications
WB, IF-Cell, IHC-P, FC
Target Molecular Weight
Predicted band size: 262 kDa
Positive Control
Rat brain tissue, human kidney tissue, human placenta tissue, mouse brain tissue, 293T.
Conjugation
unconjugated
RRID
Product Features
Form
Liquid
Concentration
1 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG
Purification Method
Immunogen affinity purified.
Application Dilution
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WB
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1:500
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IF-Cell
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1:50-1:200
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IHC-P
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1:50-1:200
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FC
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1:50-1:100
Target
Function
The R-type calcium channel is a type of voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms the pore through which calcium enters the cell and determines most of the channel's properties. This α1 subunit is also known as the calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) or Cav2.3 which in humans is encoded by the CACNA1E gene. They are strongly expressed in cortex, hippocampus, striatum, amygdala and interpeduncular nucleus. They are poorly understood, but like Q-type calcium channels, they appear to be present in cerebellar granule cells. They have a high threshold of activation and relatively slow kinetics.
Background References
1. Suzuki T et al. Mutations in EFHC1 cause juvenile myoclonic epilepsy. Nat Genet 36:842-849 (2004).
2. Schneider T et al. Molecular analysis and functional expression of the human type E neuronal Ca2+ channel alpha 1 subunit. Recept Channels 2:255-270 (1994).
Sequence Similarity
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily.
Tissue Specificity
Expressed in neuronal tissues and in kidney.
Subcellular Location
Membrane.
Synonyms
alpha-1 polypeptide antibody
BII antibody
Brain calcium channel II antibody
CAC 1E antibody
CAC1E antibody
CAC1E_HUMAN antibody
CACH 6 antibody
CACH6 antibody
CACNA1E antibody
Cacnl1 a6 antibody
ExpandImages
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ICC staining CaV2.3 in LOVO cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
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Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-CaV2.3 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-CaV2.3 antibody. Counter stained with hematoxylin.
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Immunohistochemical analysis of paraffin-embedded mouse testis tissue using anti-CaV2.3 antibody. Counter stained with hematoxylin.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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