LAMP2a Rabbit Polyclonal Antibody

Function

Lysosome-associated membrane proteins (LAMP) are glycosylated type I membrane proteins that play a role in the biogenesis of the pigment melanin. LAMP-1 (also designated CD107A) and LAMP-2 (also designated CD107B) are involved in a variety of functions, including cellular adhesion, and are thought to participate in the process of tumor invasion and metastasis. Newly synthesized LAMP-1 and LAMP-2 proteins are sorted at the trans Golgi network and are transported intracellularly via a pathway that is distinct from the clathrin-coated vesicles used for the mannose-6 phosphate receptor. LAMP-1 is expressed on the surface of thrombin-activated but not resting platelets, and it is thought to be involved in the adhesive, prothrombic properties of these cells. Both LAMP-1 and LAMP-2 are involved in maintaining lysosome acidity and protecting the lysosomal membranes from autodigestion, and their expression is increased in patients with lysosomal storage disorders.

Background References

暂无

Sequence Similarity

Belongs to the LAMP family.

Tissue Specificity

Isoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle. Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver. Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta.

Post-translational Modification

O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.

Subcellular Location

Plasma membrane. Endosome. Lysosome.

UNIPROT

SwissProt: P13473 Human

Synonyms

CD107 antigen-like family member B antibody

CD107b antibody

LAMP 2 antibody

Lamp 2a antibody

LAMP-2 antibody

LAMP2 antibody

LAMP2_HUMAN antibody

Lysosome-associated membrane glycoprotein 2 antibody

Lysosome-associated membrane protein 2 antibody