Tle6 Rabbit Polyclonal Antibody

Function

The Notch signaling pathway controls various cellular interactions that are important for the specification of a variety of fates in both vertebrates and invertebrates. Key players in the Notch pathway are the TLE genes (for transducin-like enhancer of split, also designated ESG for enhancer of split groucho), which are human homologs of the Drosophila groucho gene. TLE6 (transducin-like enhancer of split 6), also known as GRG6, is a 449 amino acid cytoplasmic protein belonging to the WD repeat groucho/TLE family. As a member of the subcortical maternal complex (SCMC), TLE6 is essential for zygotes to progress beyond the first embryonic cell divisions. TLE6 contains seven WD repeats, a motif known to mediate protein-protein interactions. The WD40 repeat family of proteins is suggested to be involved in signal transduction, RNA processing, gene regulation, vesicular trafficking, cytoskeletal assembly and may play a role in the control of cytotypic differentiation.

Background References

1. Zhang M et al. Identification of Novel Biallelic TLE6 Variants in Female Infertility With Preimplantation Embryonic Lethality. Front Genet. 2021 Jun

2. Mao B et al. A novel TLE6 mutation, c.541+1G>A, identified using whole-exome sequencing in a Chinese family with female infertility. Mol Genet Genomic Med. 2021

Sequence Similarity

Belongs to the WD repeat Groucho/TLE family.

Subcellular Location

Nucleus. Cytoplasm.

UNIPROT

SwissProt: Q9H808 Human

SwissProt: Q9WVB3 Mouse

Synonyms

Transducin-like enhancer protein 6

TLE6