AMACR Mouse Monoclonal Antibody [6F5]

Function

AMACR, is an enzyme that responsible for converting (2R)-methylacyl-CoA esters to their (2S)-methylacyl-CoA epimers and known substrates, including coenzyme A esters of pristanic acid (mostly derived from phytanic acid, a 3-methyl branched-chain fatty acid that is abundant in the diet) and bile acids derived from cholesterol. Both decreased and increased levels of the enzyme in humans are linked with diseases. Reduction of the protein level or activity results in the accumulation of (2R)-methyl fatty acids such as bile acids which causes neurological symptoms. Increased levels of AMACR protein concentration and activity are associated with prostate cancer, and the enzyme is used widely as a biomarker (known in cancer literature as P504S) in biopsy tissues. Increased levels of AMACR are also associated with some breast, colon, and other cancers, but it is unclear exactly what the role of AMACR is in these cancers. This AMACR antibody is intended for qualified laboratories to qualitatively identify by light microscopy the presence of associated antigens in sections of formalinfixed, paraffin-embedded tissue sections using IHC test methods.

Background References

1. Ouyang B et al. α-Methylacyl-CoA racemase spliced variants and their expression in normal and malignant prostate tissues. Urology 77(1):249.e1-7 (2011).

2. Ferdinandusse S et al. Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy. Nature Genetics 24(2):188-91 (2000).

Sequence Similarity

Belongs to the CoA-transferase III family.

Subcellular Location

Mitochondrion. Peroxisome.

UNIPROT

SwissProt: Q9UHK6 Human

SwissProt: O09174 Mouse

SwissProt: P70473 Rat

Synonyms