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CTHRC1 Mouse Monoclonal Antibody [5H1]

Usd: 350

Specification

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Catalog# EM1701-36

CTHRC1 Mouse Monoclonal Antibody [5H1]

Application

  • WB

  • IHC-P

Reactivity

  • Human

  • Rat

Predicted reactivity

  • Mouse

Predicted species support after-sales service
Conjugation

  • unconjugated

This product has been cited in peer reviewed publications, see list HERE

Overview

Product Name

CTHRC1 Mouse Monoclonal Antibody [5H1]

Antibody Type

Mouse Monoclonal Antibody

Immunogen

Recombinant protein within Human CTHRC1 aa 1-243 / 243.

Species Reactivity

Human, Rat (Predicted: Mouse)

Predicted species support after-sales service

Validated Applications

WB, IHC-P

Molecular Weight

Predicted band size: 26 kDa

Positive Control

CTHRC1 recombinant protein, rat large intestine tissue, human kidney tissue, human placenta tissue.

Conjugation

unconjugated

Clone Number

5H1

RRID

AB_3068761

Product Features

Form

Liquid

Concentration

Storage Instructions

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Isotype

IgG1

Purification Method

Protein A affinity purified.

Application Dilution

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:50-1:200

Target

Function

CTHRC1 (collagen triple helix repeat containing 1) is a 243 amino acid secreted protein that localizes to the extracellular matrix and contains one collagen-like domain. Expressed as two alternatively spliced isoforms, the first of which is expressed in calcified atherosclerotic plaque and chondrocyte-like cells, CTHRC1 is thought to function as a negative regulator of collagen matrix deposition and may also play a role in the stabilization of ligand-receptor interactions in the Wnt pathway. CTHRC1 is widely present in a variety of cancers, including melanoma and breast carcinoma, and may participate in cancer cell migration and cancer tissue invasion and metastasis. The gene encoding CTHRC1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies.

Background References

1. Pyagay P et al. Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. Circ. Res. 96:261-268 (2005).

2. Eriksson J et al. Gene expression analyses of primary melanomas reveal CTHRC1 as an important player in melanoma progression. Oncotarget 7:15065-92 (2016).

Tissue Specificity

Isoform 1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells.

Post-translational Modification

N-glycosylated.

Subcellular Location

Extracellular matrix. Secreted.

UNIPROT

SwissProt: Q96CG8 Human

SwissProt: Q9D1D6 Mouse

SwissProt: Q8CG08 Rat

Synonyms

Collagen triple helix repeat containing 1 antibody

Collagen triple helix repeat containing protein 1 antibody

Collagen triple helix repeat-containing protein 1 antibody

CTHR1_HUMAN antibody

Cthrc1 antibody

NMTC1 protein antibody

Protein NMTC1 antibody

Images

  • Western blot analysis of CTHRC1 on CTHRC1 recombinant protein using anti-CTHRC1 antibody at 1/500 dilution.

    Western blot analysis of CTHRC1 on CTHRC1 recombinant protein using anti-CTHRC1 antibody at 1/500 dilution.

  • Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-CTHRC1 antibody. Counter stained with hematoxylin.

    Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-CTHRC1 antibody. Counter stained with hematoxylin.

  • Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-CTHRC1 antibody. Counter stained with hematoxylin.

    Immunohistochemical analysis of paraffin-embedded human placenta tissue using anti-CTHRC1 antibody. Counter stained with hematoxylin.

  • Immunohistochemical analysis of paraffin-embedded rat large intestine tissue using anti-CTHRC1 antibody. Counter stained with hematoxylin.

    Immunohistochemical analysis of paraffin-embedded rat large intestine tissue using anti-CTHRC1 antibody. Counter stained with hematoxylin.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

Citation