Lane 1: K562
Lane 2: HepG2
Lane 3: A431
Recombinant Rabbit monoclonal primary
67kDa Laminin Receptor Recombinant Rabbit Monoclonal Antibody [JF0955] (ET1702-05)
K562, A431, RH-35, MCF-7, Hela, HepG2, human gastric carcinoma tissue, mouse kidney tissue, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
67kDa Laminin Receptor
34/67 kDa laminin receptor antibody; 37 kDa laminin receptor precursor antibody; 37/67 kDa laminin receptor antibody; 37LRP antibody; 40S ribosomal protein SA antibody; 67 kDa laminin receptor antibody; 67LR antibody; Colon carcinoma laminin binding protein antibody; Colon carcinoma laminin-binding protein antibody; LAMBR antibody; Laminin receptor 1 antibody; Laminin-binding protein precursor p40 antibody; LAMR 1 antibody; LamR antibody; LAMR1 antibody; LBP antibody; LBP/p40 antibody; LRP antibody; LRP/LR antibody; Multidrug resistance associated protein MGr1 Ag antibody; Multidrug resistance associated protein MGr1Ag antibody; Multidrug resistance-associated protein MGr1-Ag antibody; NEM/1CHD4 antibody; p40 antibody; Ribosomal Protein SA antibody; rpsA antibody; RSSA_HUMAN antibody; SA antibody
Belongs to the universal ribosomal protein uS2 family.
Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.; Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.
Cell membrane, Nucleus, Cytoplasm.
Laminin receptor (Laminin-R) has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as Fibronectin and Vitronectin. Incorporation of Laminin-R into lysosomal membranes makes it possible for lysosomes to attach to surfaces coated with Laminin. This and other properties identify Laminin-R as a member of the integrin family of cell adhesion receptors. The Laminin-R precursor is a polypeptide whose expression is consistently upregulated in aggressive carcinoma. The precursor, which is also identified as p40 ribosome-associated protein, appears to be a multifunctional protein involved in the translational machinery. Laminin-R (also known as colon carcinoma laminin-binding protein) and is found at nine-fold higher levels in colon carcinoma than in adjacent normal colonic epithelium. Additionally, the level of the Laminin-R is higher in the lung cancer cell line than in the lung cell line.