5HT2C Receptor Recombinant Rabbit Monoclonal Antibody [JA31-31] (ET1704-87)

UNIPROT #

P28335

PROTEIN NAME

5HT2C Receptor

SYNONYMS

5 Hydroxytryptamine 2C receptor antibody;5-HT-1C antibody;5-ht-1c receptor antibody;5-HT-2C antibody;5-HT1C antibody;5-HT2C antibody;5-HTR2C antibody;5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled antibody;5-hydroxytryptamine receptor 1C antibody;5-hydroxytryptamine receptor 2C antibody;5HT1C antibody;5HT2C antibody;5HT2C_HUMAN antibody;5HTR2C antibody;5Hydroxytryptamine 2C receptor antibody;Htr1c antibody;HTR2C antibody;serotonin 1c receptor antibody;serotonin 2c receptor antibody;Serotonin 5-HT-2C receptor antibody;Serotonin receptor 2C antibody

SEQUENCE SIMILARITIES

Belongs to the G-protein coupled receptor 1 family.

TISSUE SPECIFICITY

Detected in brain.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated.

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone.