Lane 1: A431 cell lysate
Lane 2: K562 cell lysate
Recombinant Rabbit monoclonal primary
5HT2C Receptor Recombinant Rabbit Monoclonal Antibody [JA31-31] (ET1704-87)
A431 cell lysate, K562 cell lysate, mouse brain tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
5 Hydroxytryptamine 2C receptor antibody; 5-HT-1C antibody; 5-ht-1c receptor antibody; 5-HT-2C antibody; 5-HT1C antibody; 5-HT2C antibody; 5-HTR2C antibody; 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled antibody; 5-hydroxytryptamine receptor 1C antibody; 5-hydroxytryptamine receptor 2C antibody; 5HT1C antibody; 5HT2C antibody; 5HT2C_HUMAN antibody; 5HTR2C antibody; 5Hydroxytryptamine 2C receptor antibody; Htr1c antibody; HTR2C antibody; serotonin 1c receptor antibody; serotonin 2c receptor antibody; Serotonin 5-HT-2C receptor antibody; Serotonin receptor 2C antibody
Belongs to the G-protein coupled receptor 1 family.
Detected in brain.
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone.