5 Lipoxygenase Rabbit Polyclonal Antibody (R1512-14)

UNIPROT #

P09917

PROTEIN NAME

5 Lipoxygenase

SYNONYMS

5 LO antibody;5 LOX antibody;5-lipoxygenase antibody;5-LO antibody;5-LOX antibody;5LOX antibody;5LPG antibody;ALOX 5 antibody;Alox5 antibody;Arachidonate 5 lipoxygenase antibody;Arachidonate 5-lipoxygenase antibody;arachidonic 5-lipoxygenase alpha-10 isoform antibody;arachidonic 5-lipoxygenase delta-10-13 isoform antibody;arachidonic 5-lipoxygenase delta-13 isoform antibody;arachidonic 5-lipoxygenase delta-p10 isoform antibody;Arachidonic acid 5 lipoxygenase antibody;Leukotriene A4 synthase antibody;LOG 5 antibody;LOG5 antibody;LOX5_HUMAN antibody;MGC163204 antibody

SEQUENCE SIMILARITIES

Belongs to the lipoxygenase family.

POST-TRANSLATIONAL MODIFICATION

Serine phosphorylation by MAPKAPK2 is stimulated by arachidonic acid. Phosphorylation on Ser-524 by PKA has an inhibitory effect. Phosphorylation on Ser-272 prevents export from the nucleus. Phosphorylation at Ser-524 is stimulated by 8-bromo-3',5'-cyclic AMP or prostaglandin E2.

SUBCELLULAR LOCATION

Cytoplasm, Membrane, Nucleus.

FUNCTION

5-lipoxygenase (5-LO) is expressed primarily in polymorphonuclear leukocytes, macrophages, and mast cells. 5-LO performs the first two catalytic reactions in the biosynthesis of leukotrienes, lipid metabolites that induce contractions of airway smooth muscle and increase vascular permeability during anaphylaxis. The cellular localization of 5-LO varies between cell types. In activated blood polymorphonuclear leukocytes 5-LO undergoes calcium dependent translocation from the cytosol to the nuclear envelope. In alveolar macrophages, the majority of 5-LO is localized in the nucleus and, upon activation of these cells, intranuclear 5-LO binds to the nuclear membrane. This intracellular shuttling of 5-LO is dependent on the association with various signaling molecules, phosphorylation and the presence of a distinct